Toothpaste containing certain plant-derived extracts was found to be effective in the prevention or treatment of gingivitis and early-stage periodontitis, according to a study published in Dentistry Journal. The authors noted that people should still get regular, in-depth cleanings and treatments to maintain oral hygiene, and that antibacterial herbal extracts have safer toxicity profiles for human use.

In the double-blind, placebo-controlled trial, patients with a previous diagnosis of gingivitis or initial stages of periodontitis were given an experimental toothpaste or the control toothpaste for a 60-day trial period, during which time they brushed twice daily. The experimental toothpaste contained chemical components and extracts of German chamomile, sage, arnica and echinacea. The control toothpaste contained only chemical active ingredients. 

The herbs used in the study showed positive anti-inflammatory, antioxidant, antiseptic and antibacterial actions. Patients in the experimental group experienced diminished bleeding of the gums and teeth whitening. The indices of gingivitis, general oral hygiene, plaque, tartar buildup and mild periodontitis decreased in both groups over the trial period. While both toothpastes eliminated several bacterial periodontal pathogens, the experimental one was more efficient against several of them.